Please use this identifier to cite or link to this item:
Title: Variability of plasma phenobarbitone concentration in Asian children in Singapore
Authors: Lee, H.S. 
Issue Date: 1984
Citation: Lee, H.S. (1984). Variability of plasma phenobarbitone concentration in Asian children in Singapore. Therapeutic Drug Monitoring 6 (2) : 182-188. ScholarBank@NUS Repository.
Abstract: In a study with 113 Asian children in which phenobarbitone was used as the sole antiepileptic drug in 75 children, including Chinese, Malays, and Indians, the mean phenobarbitone dosage required to produce a plasma level of 15 μg/ml was 5.2 mg/kg/day. While the mean plasma level/dose ratio varied, the differences between the three ethnic groups were not statistically significant. Also of little difference were the ratios between the male and female groups. For those patients with poor seizure control, however, the mean plasma level/dose ratio was significantly lower than in those whose seizures were controlled. Using additional anticonvulsant drugs concurrently with phenobarbitone in 40 children raised the mean plasma level/dose ratios significantly in each ethnic group. Further, the greater age level in those given additional antiepileptic drugs might have contributed slightly to a higher mean plasma level/dose ratio.
Source Title: Therapeutic Drug Monitoring
ISSN: 01634356
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Jul 19, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.