Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/133955
DC Field | Value | |
---|---|---|
dc.title | Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle | |
dc.contributor.author | Gwee, M.C.E. | |
dc.contributor.author | Cheah, L.S. | |
dc.date.accessioned | 2016-12-20T08:41:53Z | |
dc.date.available | 2016-12-20T08:41:53Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | Gwee, M.C.E., Cheah, L.S. (1992). Ranitidine inhibits adrenergic transmission in the rat isolated anococcygeus muscle. Clinical and Experimental Pharmacology and Physiology 19 (6) : 411-413. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03051870 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133955 | |
dc.description.abstract | 1. The effects of ranitidine on adrenergic transmission in the rat isolated anococcygeus muscle were investigated. 2. Cumulative doses (2-8 mmol/L) of ranitidine produced a concentration-dependent inhibition of motor responses of the rat isolated anococcygeus muscle evoked by field stimulation (20-25 V, 10 Hz for 10 s, 1 ms pulse width) every 2 min, but also potentiated the contractile response to exogenous noradrenaline (5 μmol/L). The inhibited motor responses recovered rapidly and completely after washing out ranitidine. 3. 4-Aminopyridine (100 μmol/L) effectively reversed the partially inhibited (55% or greater) motor responses. 4. The results strongly suggest that ranitidine can inhibit adrenergic transmission in the anococcygeus muscle by a prejunctional mechanism with, presumably, consequent development of supersensitivity of the effector cells to noradrenaline. | |
dc.subject | 4-aminopyridine | |
dc.subject | Adrenergic transmission | |
dc.subject | Anococcygeus | |
dc.subject | Prejunctional inhibition | |
dc.subject | Ranitidine | |
dc.type | Article | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.sourcetitle | Clinical and Experimental Pharmacology and Physiology | |
dc.description.volume | 19 | |
dc.description.issue | 6 | |
dc.description.page | 411-413 | |
dc.description.coden | CEXPB | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.