Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/133954
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dc.titleRanitidine inhibits adrenergic but not nonadrenergic noncholinergic transmission in the rat isolated anococcygeus muscle
dc.contributor.authorGwee, M.C.E.
dc.contributor.authorCheah, L.S.
dc.date.accessioned2016-12-20T08:41:52Z
dc.date.available2016-12-20T08:41:52Z
dc.date.issued1993
dc.identifier.citationGwee, M.C.E., Cheah, L.S. (1993). Ranitidine inhibits adrenergic but not nonadrenergic noncholinergic transmission in the rat isolated anococcygeus muscle. Archives Internationales de Pharmacodynamie et de Therapie 321 : 92-102. ScholarBank@NUS Repository.
dc.identifier.issn00039780
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133954
dc.description.abstractThe effects of ranitidine on adrenergic and nonadrenergic noncholinergic transmission in the rat isolated anococcygeus muscle and on the contractile responses of the muscle to noradrenaline, potassium chloride, 5-hydroxytryptamine and carbachol were investigated. Ranitidine (2-8 mM) produced a concentration-dependent and readily reversible inhibition of motor (excitatory) responses of the anococcygeus muscle evoked via field stimulation (20-30 V, 10 Hz x 10 sec, 1 msec pulse width, every 2 min), whereas the contractile response of the anococcygeus muscle to exogenous noradrenaline (3 μM) was potentiated by 57 ± 3.7%; the contractile response to potassium chloride (50 mM) was only slightly decreased, whereas the responses to carbachol (3 μM) or 5-hydroxytryptamine (30 μM) were completely inhibited by ranitidine (8 mM). When the tone of the muscle was raised by noradrenaline (3 μM) after complete inhibition of the motor responses by ranitidine (8 mM), field stimulation produced relaxant (inhibitory) responses which were inhibited by tetrodotoxin (2 μM) or N(G)-nitro-L-arginine methylester (50 μM). Similar results were obtained with guanethidine (0.5-3 μM) on adrenergic and nonadrenergic noncholinergic transmission. The results clearly show that ranitidine can selectively inhibit adrenergic transmission in the anococcygeus muscle with consequent unmasking of nonadrenergic noncholinergic transmission; ranitidine can also produce a supersensitivity-type response of the muscle to exogenous noradrenaline but not to potassium chloride, carbachol or 5-hydroxytryptamine. Thus, the inhibition of adrenergic transmission by ranitidine in the rat isolated anococcygeus muscle closely resembles the action of guanethidine on adrenergic transmission.
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.sourcetitleArchives Internationales de Pharmacodynamie et de Therapie
dc.description.volume321
dc.description.page92-102
dc.description.codenAIPTA
dc.identifier.isiutNOT_IN_WOS
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