Please use this identifier to cite or link to this item:;2-#
Title: Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors
Authors: Ng, N.-K.
Lee, H.-S. 
Wong, P.T.-H. 
Keywords: 5-hydroxytryptamine
Dopamine release
Rat striatum
Issue Date: 1-Mar-1999
Citation: Ng, N.-K., Lee, H.-S., Wong, P.T.-H. (1999-03-01). Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors. Journal of Neuroscience Research 55 (5) : 600-607. ScholarBank@NUS Repository.;2-#
Abstract: Dopamine (DA) release in the striatum is regulated by 5- hydroxytryptamine (5-HT, serotonin) through putative heteroreceptors. However, the effect of 5-HT is controversial. The present study investigated the effects of different 5-HT receptor ligands on DA release in the rat striatum by using in vivo microdialysis in conscious and freely moving rats. Perfusion with 5-carboxamidotryptamine, anpirtoline, pindobind-5-HT(1A), and isamoltane demonstrated the involvement of 5-HT(1A) and 5-HT(1B) receptors in facilitating DA release. In contrast, 5-HT2 receptors mediated inhibition of DA efflux, as shown by experiments with DOI [R-(-)-1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane] and ketanserin. A 5-HT3 agonist (1-(m- chlorophenyl)-biguanide hydrochloride) did not have any effect. None of the agonists used affected DA uptake into striatal synaptosomes. Unilateral 6- hydroxydopamine lesioning of the nigrostriatal DA pathway led to a selective decrease in 5-HT2 receptors. It is concluded that there are 5-HT2 heteroreceptors at the dopaminergic terminals that mediate inhibition of DA release. Further investigation is required to clarify the localization of the 5-HT1 receptors in the striatum.
Source Title: Journal of Neuroscience Research
ISSN: 03604012
DOI: 10.1002/(SICI)1097-4547(19990301)55:53.0.CO;2-#
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on May 30, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.