Please use this identifier to cite or link to this item: https://doi.org/10.1006/exmp.1993.1020
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dc.titleSuperoxide production by neutrophils from diabetics and normal subjects in response to glucose and galactose
dc.contributor.authorLin, X.
dc.contributor.authorCandlish, J.K.
dc.contributor.authorThai, A.C.
dc.date.accessioned2016-12-20T08:41:34Z
dc.date.available2016-12-20T08:41:34Z
dc.date.issued1993
dc.identifier.citationLin, X., Candlish, J.K., Thai, A.C. (1993). Superoxide production by neutrophils from diabetics and normal subjects in response to glucose and galactose. Experimental and Molecular Pathology 58 (3) : 229-236. ScholarBank@NUS Repository. https://doi.org/10.1006/exmp.1993.1020
dc.identifier.issn00144800
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133926
dc.description.abstractGlucose added to the medium was found to enhance superoxide production by isolated circulating neutrophils from both diabetic and normal subjects, but quantitatively the enhancement decreased from 4 to 50 mmole/liter. Galactose up to 50 mmole/liter had no effect on superoxide production in cells from the control subjects, but appeared to depress it in those from diabetics. No correlations were found between indices of the degree of hyperglycemia (plasma glucose and hemoglboin A(1c)) and the magnitude of the respiratory burst in cells from diabetics. When the isolated cells from normal and diabetic subjects were restored to a medium containing glucose at the original concentration in plasma at phlebotomy, the rate of superoxide production was approximately doubled in every case and there was no significant difference between diabetic and normal cells. Preincubation of cells for 1 hr in the presence of 0-50 mmole/liter glucose or galactose prior to activation had no significantly depressant effect on the respiratory burst except at 50 mmole/liter glucose in diabetic cells. It is concluded that circulating neutrophils from the diabetic population under the conditions studied are just as competent as control cells in their ability to sustain superoxide production over a wide range of energy availability.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1006/exmp.1993.1020
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.description.doi10.1006/exmp.1993.1020
dc.description.sourcetitleExperimental and Molecular Pathology
dc.description.volume58
dc.description.issue3
dc.description.page229-236
dc.description.codenEXMPA
dc.identifier.isiutA1993LK30400007
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