Please use this identifier to cite or link to this item: https://doi.org/10.1093/humrep/13.12.3371
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dc.titleThe performance of levonorgestrel rod and Norplant® contraceptive implants: A 5 year randomized study
dc.contributor.authorSivin, I.
dc.contributor.authorCampodonico, I.
dc.contributor.authorKiriwat, O.
dc.contributor.authorHolma, P.
dc.contributor.authorDiaz, S.
dc.contributor.authorWan, L.
dc.contributor.authorBiswas, A.
dc.contributor.authorViegas, O.
dc.contributor.authorAbdalla, K.E.D.
dc.contributor.authorAnant, M.P.
dc.contributor.authorPavez, M.
dc.contributor.authorStern, J.
dc.date.accessioned2016-12-20T08:39:56Z
dc.date.available2016-12-20T08:39:56Z
dc.date.issued1998
dc.identifier.citationSivin, I., Campodonico, I., Kiriwat, O., Holma, P., Diaz, S., Wan, L., Biswas, A., Viegas, O., Abdalla, K.E.D., Anant, M.P., Pavez, M., Stern, J. (1998). The performance of levonorgestrel rod and Norplant® contraceptive implants: A 5 year randomized study. Human Reproduction 13 (12) : 3371-3378. ScholarBank@NUS Repository. https://doi.org/10.1093/humrep/13.12.3371
dc.identifier.issn02681161
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133777
dc.description.abstractA new contraceptive (LNG rod implants, Jadelle®, Leiras Oy's registered trademark for rod implants) was prospectively evaluated in randomized 5 year comparison with Norplant® (Population Council's registered trademark for contraceptive implants releasing levonorgestrel) capsule implants. The study involved 1198 women at seven centres. No pregnancies occurred in the first 4 years. At 5 years, the cumulative pregnancy rate was 1 per 100 users or less for each regimen. Annual discontinuation rates averaged 11-12 per 100 users (P > 0.05), corresponding to 5 year continuation rates of 55.1 for rods and 53.0 per 100 for capsules. Mean annual discontinuation rates for menstrual disturbances were 3.5 and 4.2 per 100 for rod and capsule implants respectively (P > 0.05), and mean annual removal rates for medical problems were 3.5 and 3.0 per 100 (P > 0.05) respectively. Apart from menstrual problems, headache, weight gain and acne were the principal medical reasons for removal. In proportional hazard analyses, family formation variables, age, parity and desire/non desire for another child, recorded at admission, significantly affected discontinuation rates for major decrement categories and for all reasons combined. Mean rod removal time was half that of Norplant (P < 0.01); complications of rod removal were at a lower rate. With these contraceptives indistinguishable in performance except for ease and speed of removal. LNG rod implants appear to be preferable to Norplant for use through 5 years by virtue of relative ease of removal.
dc.subjectContraception
dc.subjectLevonorgestrel
dc.subjectRandomized studies
dc.subjectRod implants
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1093/humrep/13.12.3371
dc.description.sourcetitleHuman Reproduction
dc.description.volume13
dc.description.issue12
dc.description.page3371-3378
dc.description.codenHUREE
dc.identifier.isiut000077774500020
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