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dc.titleMechanistic investigations on drug delivery from alginate matrices
dc.contributor.authorCHING AI LING
dc.identifier.citationCHING AI LING (2007-08-23). Mechanistic investigations on drug delivery from alginate matrices. ScholarBank@NUS Repository.
dc.description.abstractThis study investigated the influence of various physicochemical properties of alginates on drug release from alginate matrices. The particle size of constituent alginate particles affected the burst release phase in acid media, suggesting its role in the diffusion barrier development. Higher viscosity alginate reduced the rate of alginic acid barrier formation but formed less erodible gel barrier at pH 6.8. Alginate MG ratio influenced matrix integrity. High-G alginate matrices showed greater propensity to crack or laminate at acidic pH compared to high-M alginate matrices. Cracks compromised diffusion barrier integrity and were associated with the protonation of sodium alginate. Incorporation of pH-modifiers caused transient micro-environmental pH elevation which impeded alginate protonation, thus minimizing matrix lamination. Matrices with cross-linked barrier resisted crack development, even with gradual conversion to alginic acid. The dissolution performance of alginate matrix at gastric pH was governed by the preservation of its integrity.
dc.subjectalginate, cross-linking, pH-modifier, lamination, anisotropy, pH-sensitive
dc.contributor.supervisorCHAN LAI WAH
dc.contributor.supervisorHENG WAN SIA, PAUL
dc.contributor.supervisorLIEW, CELINE VALERIA
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
Appears in Collections:Ph.D Theses (Open)

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