Please use this identifier to cite or link to this item: https://doi.org/10.1515/JPM.1999.024
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dc.titleThe sensitivity of the trivariate analysis using maternal serum alpha-feto protein, human chorionic gonadotrophin and maternal age in screening for fetal aneuploidy in mothers above the age of 35
dc.contributor.authorAnandakumar, C.
dc.contributor.authorChew, S.
dc.contributor.authorWong, Y.C.
dc.contributor.authorGoh, V.H.H.
dc.contributor.authorTain, C.F.
dc.contributor.authorRatnam, S.S.
dc.date.accessioned2016-12-20T08:39:48Z
dc.date.available2016-12-20T08:39:48Z
dc.date.issued1999
dc.identifier.citationAnandakumar, C., Chew, S., Wong, Y.C., Goh, V.H.H., Tain, C.F., Ratnam, S.S. (1999). The sensitivity of the trivariate analysis using maternal serum alpha-feto protein, human chorionic gonadotrophin and maternal age in screening for fetal aneuploidy in mothers above the age of 35. Journal of Perinatal Medicine 27 (3) : 178-182. ScholarBank@NUS Repository. https://doi.org/10.1515/JPM.1999.024
dc.identifier.issn03005577
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133765
dc.description.abstractThis study was undertaken to assess the usefulness of maternal serum human chorionic gonadotrophin, alpha-fetoprotein and maternal age in screening for fetuses with abnormal chromosomes in pregnant women aged 35 years and over. From 1989 to 1991, 1208 women seen at the National University Hospital had karyotyping procedures performed for maternal age > 35 years as well as second trimester serum samples taken for alpha-fetoprotein and human chorionic gonadotrophin. Sixteen (1.3%) chromosomal abnormalities were present. Using cut off risk levels of 1:250 and 1:384, the sensitivity of the analysis in screening for Down's syndrome pregnancies was 71.5% and 86% respectively. For the non Down's chromosomal abnormalities, using cut off risk levels of 1:250 and 1:384, the sensitivity of the analysis was only 22.3% and 33.4% respectively. Thus risk calculations based on the two serum markers and maternal age failed to identify all fetuses with abnormal chromosomes.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1515/JPM.1999.024
dc.subjectAlpha-fetoprotein
dc.subjectFetal chromosomal abnormalities
dc.subjectMaternal serum HCG
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1515/JPM.1999.024
dc.description.sourcetitleJournal of Perinatal Medicine
dc.description.volume27
dc.description.issue3
dc.description.page178-182
dc.description.codenJPEMA
dc.identifier.isiut000081719400005
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