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Title: | Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates | Authors: | Kottegoda, S.R. Adaikan, P.G. Karim, S.M.M. |
Issue Date: | Apr-1982 | Citation: | Kottegoda, S.R., Adaikan, P.G., Karim, S.M.M. (1982-04). Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates. Prostaglandins, Leukotrienes and Medicine 8 (4) : 343-348. ScholarBank@NUS Repository. | Abstract: | 17(S)methyl-ω-homo trans δ2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male monkeys and three female baboons. Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST segment (1 baboon and 1 monkey) and inversion of T wave (1 baboon). Inverted T waves were also present in one baboon and one monkey prior to any drug administration. In four out of seven animals, bolus intravenous doses (5 to 15 μg/kg) of ONO 1206 reversed the ECG changes produced by vasopressin and in one animal ONO 1206 reversed the existing inverted T wave. These findings indicate that vasopressin is a suitable agent for the induction of coronary vasoconstriction in primates and that ONO 1206 is able to reverse this effect. © 1982. | Source Title: | Prostaglandins, Leukotrienes and Medicine | URI: | http://scholarbank.nus.edu.sg/handle/10635/133677 | ISSN: | 02621746 |
Appears in Collections: | Staff Publications |
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