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Title: Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates
Authors: Kottegoda, S.R.
Adaikan, P.G. 
Karim, S.M.M.
Issue Date: Apr-1982
Citation: Kottegoda, S.R., Adaikan, P.G., Karim, S.M.M. (1982-04). Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates. Prostaglandins, Leukotrienes and Medicine 8 (4) : 343-348. ScholarBank@NUS Repository.
Abstract: 17(S)methyl-ω-homo trans δ2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male monkeys and three female baboons. Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST segment (1 baboon and 1 monkey) and inversion of T wave (1 baboon). Inverted T waves were also present in one baboon and one monkey prior to any drug administration. In four out of seven animals, bolus intravenous doses (5 to 15 μg/kg) of ONO 1206 reversed the ECG changes produced by vasopressin and in one animal ONO 1206 reversed the existing inverted T wave. These findings indicate that vasopressin is a suitable agent for the induction of coronary vasoconstriction in primates and that ONO 1206 is able to reverse this effect. © 1982.
Source Title: Prostaglandins, Leukotrienes and Medicine
ISSN: 02621746
Appears in Collections:Staff Publications

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