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Title: Investigations on keloid pathogenesis and therapy
Keywords: Keloid Scar, Epithelial-Mesenchymal Interactions, Activin-A, Proteoglycans, Stem cell factor, Gleevec
Issue Date: 30-Oct-2007
Citation: ANANDAROOP MUKHOPADHYAY (2007-10-30). Investigations on keloid pathogenesis and therapy. ScholarBank@NUS Repository.
Abstract: Keloid scars are a result of an aberration in the normal wound healing prcoess, and are characterized by overabundant collagen/ECM deposition. Several treatment modalities have been explored but none of the treatments are effective. In spite of the large number of growth factors, cytokines and chemokines that have been studied and are now known to play a role in its pathogenesis, the precise pathobiology leading to this scar formation remains largely unknown. Thus to identify new targets for therapeutic intervention, it is imperative to identify key modulators which are aberrantly expressed in keloids and to understand and assess the role of these modulators towards this fibrotic phenotype. In this study, activin-A, syndecan-2, fibroblast growth factor -2 and the stem cell factor/c-Kit system were all identified and demonstrated to play an important role in keloid pathogenesis and the effects of these growth factors was shown to be modulated by epithelial-mesenchymal interactions. Finally having identified these key targets, naturally occurring antagonists like follistatin and decorin and synthetic drugs like Gleevec were explored as potential therapeutic agents for keloid scars.
Appears in Collections:Ph.D Theses (Open)

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