Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleSubcutaneously administered recombinant human β-interferon in the treatment of chronic hepatitis B virus infection
dc.contributor.authorGuan, R.
dc.contributor.authorYeoh, K.G.
dc.contributor.authorYap, I.
dc.contributor.authorKang, J.Y.
dc.contributor.authorWee, A.
dc.contributor.authorSmith, R.
dc.identifier.citationGuan, R., Yeoh, K.G., Yap, I., Kang, J.Y., Wee, A., Smith, R. (1996). Subcutaneously administered recombinant human β-interferon in the treatment of chronic hepatitis B virus infection. Alimentary Pharmacology and Therapeutics 10 (5) : 807-814. ScholarBank@NUS Repository.
dc.description.abstractBackground: Treatment of chronic replicative hepatitis B virus (HBV) infection is aimed at stopping viral replication and preventing the development of chronic liver disease. β-Interferon treatment has been less well studied than α-interferon. Methods: The efficacy and tolerability of a 6-month course of subcutaneously administered human recombinant β-interferon (rINF-β(ser)) was studied and the results of a low-dose regime compared with a high-dose regime. Twenty patients (17 men and three women), aged 24-54 years, with chronic hepatitis B virus infection (all hepatitis B surface antigen-positive with detectable HBV-DNA in their sera for at least 3 months prior to therapy) were randomized into two treatment groups of 10 patients each. The low-dose group received 6 x 106 U/dose and the high-dose group received 30 x 106 U/dose, both groups receiving their respective doses three times a week initially for 1 month and continuing for a total of 6 months. Results: The treatment was well tolerated in both groups. None of the patients required dosage reduction or cessation of treatment because of side-effects. HBV-DNA decreased in all patients during treatment, demonstrating the anti-viral efficacy of rINF-β(ser), and was undetectable in 20 and 40% of patients receiving low-dose and high-dose regimes, respectively, at the end of 6 months treatment (P = N.S.). One year after completion of treatment, HBV-DNA was undetectable in 50 and 30% of patients in the low-dose and high-dose groups, respectively (P = N.S.). However, only one patient achieved seroconversion with loss of the hepatitis B surface antigen and appearance of an antihepatitis B 'e' antigen at the end of 18 months. Conclusion: This study shows that subcutaneously administered rINF-β(ser) is well tolerated, but the optimal dose and duration of treatment still needs to be defined by further studies.
dc.description.sourcetitleAlimentary Pharmacology and Therapeutics
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.