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Title: Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore
Authors: Wang, Y.M. 
Ng, W.C. 
Lo, S.K. 
Keywords: Coinfection
Hepatitis B virus
Hepatitis C virus
Hepatitis C virus antibody
Hepatitis C virus RNA
Issue Date: Aug-1999
Citation: Wang, Y.M., Ng, W.C., Lo, S.K. (1999-08). Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore. Journal of Gastroenterology 34 (4) : 481-485. ScholarBank@NUS Repository.
Abstract: This study was carried out to compare hepatitis B virus (HBV) and hepatitis C virus (HCV) replicative states and to determine possible interference between HBV and HCV. One thousand and sixty-one consecutive patients seen at The Gastroenterology Division of the National University Hospital of Singapore between 1988 and 1995 were screened for HBV and HCV serological markers. Anti-HCV was tested using a second-generation enzyme-linked immunosorbent assay (ELISA) method. HCV-RNA was detected by a reverse-transcription polymerase chain reaction method (RT-PCR). Data were analyzed by either paired t-test or χ 2 test. Two hundred and twenty-four patients were infected with HBV alone, while 117 patients were infected with HCV only. Thirty-one patients were coinfected with HBV and HCV. HCV-RNA was detected in 104 of the 117 HCV patients (88.9%), and in 12 of 29 coinfected patients (41.4%). Serum anti-HCV levels in the coinfected patients were lower than those in the HCV-infected patients. A significant difference for anti-HCV reactivity and HCV-RNA positivity was observed between HCV-infected patients and coinfected patients (P < 0.01). In contrast, HBV-DNA and hepatitis B envelope antigen (HBeAg) positive rates were similar in HBV carriers and patients coinfected with HBV and HCV. These results show a possible interaction between HBV and HCV life cycles, and suggest that HCV replication may be negatively affected by HBV.
Source Title: Journal of Gastroenterology
ISSN: 09441174
DOI: 10.1007/s005350050300
Appears in Collections:Staff Publications

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