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|Title:||Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore||Authors:||Wang, Y.M.
Hepatitis B virus
Hepatitis C virus
Hepatitis C virus antibody
Hepatitis C virus RNA
|Issue Date:||Aug-1999||Citation:||Wang, Y.M., Ng, W.C., Lo, S.K. (1999-08). Suppression of hepatitis C virus by hepatitis B virus in coinfected patients at the National University Hospital of Singapore. Journal of Gastroenterology 34 (4) : 481-485. ScholarBank@NUS Repository. https://doi.org/10.1007/s005350050300||Abstract:||This study was carried out to compare hepatitis B virus (HBV) and hepatitis C virus (HCV) replicative states and to determine possible interference between HBV and HCV. One thousand and sixty-one consecutive patients seen at The Gastroenterology Division of the National University Hospital of Singapore between 1988 and 1995 were screened for HBV and HCV serological markers. Anti-HCV was tested using a second-generation enzyme-linked immunosorbent assay (ELISA) method. HCV-RNA was detected by a reverse-transcription polymerase chain reaction method (RT-PCR). Data were analyzed by either paired t-test or χ 2 test. Two hundred and twenty-four patients were infected with HBV alone, while 117 patients were infected with HCV only. Thirty-one patients were coinfected with HBV and HCV. HCV-RNA was detected in 104 of the 117 HCV patients (88.9%), and in 12 of 29 coinfected patients (41.4%). Serum anti-HCV levels in the coinfected patients were lower than those in the HCV-infected patients. A significant difference for anti-HCV reactivity and HCV-RNA positivity was observed between HCV-infected patients and coinfected patients (P < 0.01). In contrast, HBV-DNA and hepatitis B envelope antigen (HBeAg) positive rates were similar in HBV carriers and patients coinfected with HBV and HCV. These results show a possible interaction between HBV and HCV life cycles, and suggest that HCV replication may be negatively affected by HBV.||Source Title:||Journal of Gastroenterology||URI:||http://scholarbank.nus.edu.sg/handle/10635/133582||ISSN:||09441174||DOI:||10.1007/s005350050300|
|Appears in Collections:||Staff Publications|
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