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Title: Validation of the MOS SF-36 for quality of life assessment of patients with systemic lupus erythematosus in Singapore
Authors: Thumboo, J.
Fong, K.-Y.
Ng, T.-P. 
Leong, K.-H.
Feng, P.-H.
Thio, S.-T.
Boey, M.-L.
Keywords: Asia
Bilag disease activity index
Quality of life
SLICC/ACR damage index
Systemic lupus erythematosus
Issue Date: 1999
Citation: Thumboo, J., Fong, K.-Y., Ng, T.-P., Leong, K.-H., Feng, P.-H., Thio, S.-T., Boey, M.-L. (1999). Validation of the MOS SF-36 for quality of life assessment of patients with systemic lupus erythematosus in Singapore. Journal of Rheumatology 26 (1) : 97-102. ScholarBank@NUS Repository.
Abstract: Objective. To assess the reliability and construct validity of the Medical Outcomes Study Short Form 36 Health Survey (SF-36) in a multiracial cohort of Asian patients with lupus in Singapore. Methods. A cross sectional study was performed on 118 English speaking patients with lupus attending a specialist rheumatology unit between March and August 1996. Patients completed a questionnaire containing the UK standard version of the SF-36 twice within a 14 day period. All patients were assessed for disease activity using the British Isles Lupus Assessment Group score (BILAG), and for disease related damage using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (DI). Relationships between SF-36, BILAG, and DI scores were studied using Spearman's rank correlation. Internal consistency of the SF-36 was assessed using Cronbach's α, and stability using the repeatability coefficient of Bland and Altman. Results. SF-36 subscales showed high internal consistency, with Cronbach's α coefficient ranging from 0.84 to 0.94. Test-retest reliability was acceptable, with Spearman's rank correlation > 0.70 for all subscales except role-physical, and mean differences in test scores of < 2 points for 5 of 8 subscales. SF-36 subscale scores were weakly correlated with BILAG scores (Spearman's p -0.37 to 0.15) and SLICC/ACR DI scores (Spearman's p -0.25 to 0.23), suggesting divergent construct validity of the SF-36. Conclusion. These data suggest the SF-36 is a reliable and valid measure of the quality of life of patients with lupus in Singapore.
Source Title: Journal of Rheumatology
ISSN: 0315162X
Appears in Collections:Staff Publications

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