Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/133499
DC Field | Value | |
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dc.title | Transformation of monocytes into amoeboid microglia and into microglia in the corpus callosum of postnatal rats, as shown by labelling monocytes by carbon particles | |
dc.contributor.author | Ling, E.A. | |
dc.date.accessioned | 2016-12-20T08:36:47Z | |
dc.date.available | 2016-12-20T08:36:47Z | |
dc.date.issued | 1979 | |
dc.identifier.citation | Ling, E.A. (1979). Transformation of monocytes into amoeboid microglia and into microglia in the corpus callosum of postnatal rats, as shown by labelling monocytes by carbon particles. Journal of Anatomy 128 (4) : 847-858. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00218782 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/133499 | |
dc.description.abstract | Two successive intravenous doses of carbon suspension were given at 24 hourly intervals into six days old rats. These animals were killed at intervals ranging from 1 to 9 days after the second injection. The corpus callosum and neighbouring structures were examined for cells containing ingested colloidal carbon particles in their cytoplasm. Twenty four hours after the second injection, a variable number of carbon-labelled monocytes were adherent to the luminal wall of blood vessels in the corpus callosum. Numerous carbon-labelled cells appeared to have left the lumen and entered the brain tissue surrounding the vessels. These perivascular carbon-labelled monocytes in the neuropil displayed a large pale nucleus with fine chromatin granules. The phagocytic amoeboid microglia in the corpus callosum were unlabelled at first, although a few cells of a similar nature in the cavum septi pellucidi did show carbon particles in their cytoplasm. Four or five days after the second carbon injection perivascular carbon-labelled monocytes were rare, but carbon particles were now present in the amoeboid microglia. At 8 days amoeboid microglia were virtually absent from the corpus callosum but carbon particles now appeared in cells which closely resembled microglia (flattened nucleus, coarse chromatin, scanty cytoplasm at one pole). | |
dc.type | Article | |
dc.contributor.department | ANATOMY | |
dc.description.sourcetitle | Journal of Anatomy | |
dc.description.volume | 128 | |
dc.description.issue | 4 | |
dc.description.page | 847-858 | |
dc.description.coden | JOANA | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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