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Title: Heart Failure Mortality in Southeast Asian Patients With Left Ventricular Systolic Dysfunction
Authors: Seow, S.-C.
Chai, P.
Lee, Y.-P.
Chan, Y.-H.
Kwok, B.W.K.
Yeo, T.-C.
Chia, B.-L. 
Keywords: Heart failure
Southeast Asian
Issue Date: Aug-2007
Citation: Seow, S.-C., Chai, P., Lee, Y.-P., Chan, Y.-H., Kwok, B.W.K., Yeo, T.-C., Chia, B.-L. (2007-08). Heart Failure Mortality in Southeast Asian Patients With Left Ventricular Systolic Dysfunction. Journal of Cardiac Failure 13 (6) : 476-481. ScholarBank@NUS Repository.
Abstract: Background: Prognostic indicators and mortality in multiethnic Southeast Asian patients with heart failure (HF) may be different. Methods and Results: The study population comprised 225 inpatients with HF with a left ventricular ejection fraction of 40% or less who were discharged alive. Five years later, survival and causes of death were determined. Proportionally, more Malay and Indian patients were admitted compared with Chinese patients (P < .001). There were 55.6% in New York Heart Association (NYHA) class III or IV. Ischemic heart disease was the most common cause (85.8%). At 5 years, 152 patients (67.5%) had died. Angiotensin-converting enzyme inhibitors were prescribed to 79.1% of patients on discharge. Cardiovascular causes accounted for 69.7% of deaths. Predictors of mortality include female gender (P = .046), age 70 years or more (P = .017), renal impairment (P = .008), NYHA class III or IV (P = .03), and non-use of angiotensin-converting enzyme inhibitors (P = .005). On multivariate analysis, increasing age (P = .001) and renal impairment (P = .019) were independent predictors of all-cause mortality. Cardiovascular death was more likely with NYHA class III or IV (P = .004) and renal impairment (P = .012). Conclusion: Mortality is unusually high in this group of patients despite treatment. Greater use of evidence-based therapies in HF-management programs may arrest this trend. © 2007 Elsevier Inc. All rights reserved.
Source Title: Journal of Cardiac Failure
ISSN: 10719164
DOI: 10.1016/j.cardfail.2007.03.010
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