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https://scholarbank.nus.edu.sg/handle/10635/133292
Title: | Hepatitis B antigen in the liver cells in cirrhosis and hepatocellular carcinoma | Authors: | Tan, A.Y.O. Law, C.H. Lee, Y.S. |
Issue Date: | 1977 | Citation: | Tan, A.Y.O., Law, C.H., Lee, Y.S. (1977). Hepatitis B antigen in the liver cells in cirrhosis and hepatocellular carcinoma. Pathology 9 (1) : 57-64. ScholarBank@NUS Repository. | Abstract: | The demonstration of hepatitis B antigen in the liver cells in formalin fixed paraffin embedded tissues by Shikata's orcein staining method affords an opportunity to conduct retrospective studies on necropsy materials. Such a study in Singapore showed orcein positive liver cells in 22 out of 52 (42.3%) and 37 out of 50 (74.0%) cases of cirrhosis of the liver and hepatocellular carcinoma respectively, while only 5 out of 113 (4.4%) 'normal' livers gave positive results. There is a significant difference in the frequency of hepatocellular carcinoma in orcein positive and orcein negative cirrhotic livers (28 out of 50, and 10 out of 40 respectively). These results suggest a possible etiologic relation between hepatitis B antigen and hepatocellular carcinoma. | Source Title: | Pathology | URI: | http://scholarbank.nus.edu.sg/handle/10635/133292 | ISSN: | 00313025 |
Appears in Collections: | Staff Publications |
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