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Title: Hepatitis B antigen in the liver cells in cirrhosis and hepatocellular carcinoma
Authors: Tan, A.Y.O. 
Law, C.H.
Lee, Y.S. 
Issue Date: 1977
Citation: Tan, A.Y.O., Law, C.H., Lee, Y.S. (1977). Hepatitis B antigen in the liver cells in cirrhosis and hepatocellular carcinoma. Pathology 9 (1) : 57-64. ScholarBank@NUS Repository.
Abstract: The demonstration of hepatitis B antigen in the liver cells in formalin fixed paraffin embedded tissues by Shikata's orcein staining method affords an opportunity to conduct retrospective studies on necropsy materials. Such a study in Singapore showed orcein positive liver cells in 22 out of 52 (42.3%) and 37 out of 50 (74.0%) cases of cirrhosis of the liver and hepatocellular carcinoma respectively, while only 5 out of 113 (4.4%) 'normal' livers gave positive results. There is a significant difference in the frequency of hepatocellular carcinoma in orcein positive and orcein negative cirrhotic livers (28 out of 50, and 10 out of 40 respectively). These results suggest a possible etiologic relation between hepatitis B antigen and hepatocellular carcinoma.
Source Title: Pathology
ISSN: 00313025
Appears in Collections:Staff Publications

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