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Title: Hyponatremia in sick children
Authors: Tay, J.S.H. 
Aiyathurai, J.E.J.
Low, P.S. 
Issue Date: 1978
Citation: Tay, J.S.H., Aiyathurai, J.E.J., Low, P.S. (1978). Hyponatremia in sick children. Journal of the Singapore Paediatric Society 20 (3) : 143-147. ScholarBank@NUS Repository.
Abstract: The profile of serum sodium (Na) and serum potassium (K) on admission in children with meningitis/ecephalitis (N = 64) was compared with those with febrile convulsions (N = 50) and acute respiratory illnesses (N = 100). Significant differences were observed. Firstly, hyponatremia (NA ≤ 132 mmol/L) was commoner with meningitis/encephalitis when compared with febrile convulsions (p < 0.002) and acute respiratory illnesses (p < 0.001). Secondly, severe hyponatremia (Na ≤ 125 mmol/L) was a more frequent observation in meningitis/encephalitis (p < 0.05). Thirdly, hyperkalemia was not associated with hyponatremia in children with meningitis/encephalitis while this was so in children with febrile convulsions (p < 0.01) and acute respiratory illnesses (p < 0.001). These differences suggest that inappropriate ADH secretion might be operative in meningitis/encephalitis, while the sick cell phenomenon is a likely explanation for the hyponatremia of the other two groups. The therapeutic implications are discussed.
Source Title: Journal of the Singapore Paediatric Society
ISSN: 00375683
Appears in Collections:Staff Publications

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