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|Title:||Predilection of the Macular Region to High Incidence of Choroidal Neovascularization after Intense Laser Photocoagulation in the Monkey||Authors:||Shen, W.-Y.
|Issue Date:||Mar-2004||Citation:||Shen, W.-Y., Lee, S.Y., Yeo, I., Lai, C.-M., Mathur, R., Tan, D., Constable, I.J., Rakoczy, P.E. (2004-03). Predilection of the Macular Region to High Incidence of Choroidal Neovascularization after Intense Laser Photocoagulation in the Monkey. Archives of Ophthalmology 122 (3) : 353-360. ScholarBank@NUS Repository. https://doi.org/10.1001/archopht.122.3.353||Abstract:||Objective: To determine the key factors for creating a high incidence model of choroidal neovascularization (CNV) in the monkey. Methods: Intense laser photocoagulation was performed in 8 eyes of 4 monkeys using krypton red and green-yellow and Alcon frequency-doubled diode ophthalmic lasers Eight to 13 lesions were delivered to an area between the temporal vascular arcades in each eye Development of CNV was monitored by fluorescein angiography at 2 and 4 weeks after laser treatment, and the results were correlated with histological analysis. Results: A much higher incidence of CNV occurred in the macular region, which refers to an anatomic area equivalent to a mean ± SD 2 5 ± 0 4 times the horizontal diameter of the optic disc in the fundus Regardless of the type of ophthalmic laser used, 72% of lesions developed fluorescein leakage within the macula, compared with 12% outside the macula (P||Source Title:||Archives of Ophthalmology||URI:||http://scholarbank.nus.edu.sg/handle/10635/133263||ISSN:||00039950||DOI:||10.1001/archopht.122.3.353|
|Appears in Collections:||Staff Publications|
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