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Title: In vitro formation of testosterone via the Δ5-pathway in the human umbilical cord
Authors: Loganath, A. 
Gunasegaram, R.
Peh, K.L.
Chow, W.P.
Chew, P.C.T.
Shanmugaratnam, S.
Keywords: 17α-hydroxylase
17β-hydroxy steroid oxidoreductase
3β-hydroxy steroid dehydrogenase-5,4-ene isomerase
androgen synthesis
fetoplacental unit (umbilical cord)
testosterone synthesis by umbilical cord
umbilical cord
Issue Date: Apr-1992
Citation: Loganath, A., Gunasegaram, R., Peh, K.L., Chow, W.P., Chew, P.C.T., Shanmugaratnam, S. (1992-04). In vitro formation of testosterone via the Δ5-pathway in the human umbilical cord. Steroids 57 (4) : 189-192. ScholarBank@NUS Repository.
Abstract: Homogenates of two groups of term umbilical cord (n = 6, 37-40 weeks; n = 6, 38-40 weeks) were separately incubated with [7n-3H]pregnenolone and [1,2,6, 7-3H]dehydroepiandrosterone. Using the reverse-isotope dilution technique, [3H]dehydroepiandrosterone and [3H] testosterone formed from the respective substrates were isolated and characterized. The extent of enzymic conversions were 0.015-0.28% and 0.044-2.2%. These results provide evidence for the metabolic transformation of pregnenolone to testosterone via the Δ5-3β-hydroxy route. © 1992.
Source Title: Steroids
ISSN: 0039128X
Appears in Collections:Staff Publications

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