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Title: Malignant ovarian germ cell tumours: Experience in the National University Hospital of Singapore
Authors: Lim, F.-K. 
Chanrachakul, B.
Chong, S.M. 
Ratnam, S.S. 
Keywords: Adjuvant chemotherapy
Endodermal sinus tumour
Immature teratoma
Tumour markers
Issue Date: Sep-1998
Citation: Lim, F.-K., Chanrachakul, B., Chong, S.M., Ratnam, S.S. (1998-09). Malignant ovarian germ cell tumours: Experience in the National University Hospital of Singapore. Annals of the Academy of Medicine Singapore 27 (5) : 657-661. ScholarBank@NUS Repository.
Abstract: Management of thirteen cases of malignant ovarian germ cell tumours was reported. Of these, 5 (38%) were immature teratoma, 3 (23%) were endodermal sinus tumour, 1 (8%) was dysgerminoma and 4 (31%) were mixed germ cell turnout. Eight (61%) had stage I, 1 (8%) had stage II and 4 (31%) had stage III diseases. Six had unilateral salpingo-oophorectomy, 6 had total abdominal hysterectomy and bilateral salpingo-oophorectomy and 1 had bilateral oophorectomy. Ten (77%) had adjuvant chemotherapy predominantly with bleomycin/ etoposide/cisplatin combination. All patients with stage I and stage H turnouts were alive with no evidence of disease at 1/2 year to 5 years followup. Of the 4 patients with stage IIIC diseases, 2 with optimal debulking surgery were alive and disease free at 4 and 7 years after surgery. The other 2 patients with stage IIIC tumours had multiple bulky residual tumours. One of them with a combination of endodermal sinus turnout and embryonal carcinoma died of progressive disease despite chemotherapy 6 months after surgery and the other with mixed endodermal sinus tumour and dysgerminoma was alive with disease at 6 months. Alpha-fetoprotein levels were raised in all 6 patients with endodermal sinus tumour, either pure or combined with other tumours. Regression of alpha-fetoprotein levels was of important prognostic significance in endodermal sinus tumour.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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