Please use this identifier to cite or link to this item:
|Title:||Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst||Authors:||Dawood, M.Y.
|Issue Date:||1975||Citation:||Dawood, M.Y., Teoh, E.S., Das, N.P. (1975). Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst. Obstetrics and Gynecology 45 (2) : 171-174. ScholarBank@NUS Repository.||Abstract:||Progesterone concentrations in 2 full term normal placentas, molar tissue from 3 cases of hydatidiform mole, and ovarian tissue from a theca lutein cyst of hydatidiform mole were measured by competitive protein binding. Sephadex LH 20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extracts were progesterone and very small amounts of 20α dihydroprogesterone and 17α hydroxyprogesterone. The concentrations of progesterone in the placentas were 368.8 and 317.2 ng/g tissue, respectively, while in molar tissue the concentrations were 2474.5, 1974.6, and 4146.0 ng/g tissue, respectively. Progesterone concentration in ovarian tissue was between 1121.2 and 1440.9 ng/g tissue. It is suggested that the high concentration of progesterone in molar tissue reflects functional capacity of the abnormal trophoblast in progesterone synthesis and accumulation of progesterone due to absence of a fetus. The lower concentration of progesterone in the ovary in molar pregnancy would appear to suggest that the ovary is a secondary source of progesterone in molar pregnancy.||Source Title:||Obstetrics and Gynecology||URI:||http://scholarbank.nus.edu.sg/handle/10635/133201||ISSN:||00297844|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 10, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.