Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/133155
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dc.titleWBP2 MEDIATES BREAST CANCER PROGRESSION VIA WNT SIGNALING
dc.contributor.authorLI ZILIN
dc.date.accessioned2016-12-14T18:00:21Z
dc.date.available2016-12-14T18:00:21Z
dc.date.issued2016-08-19
dc.identifier.citationLI ZILIN (2016-08-19). WBP2 MEDIATES BREAST CANCER PROGRESSION VIA WNT SIGNALING. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133155
dc.description.abstractBreast cancer is the most common malignancy in women worldwide and it is crucial to study the mechanism comprehensively to identify therapeutic targets. WBP2 has been reported to contribute to breast cancer cell proliferation, migration and tumor formation probably via Wnt signaling. However, the molecular mechanism of WBP2 in this process still remains unclear. Here in this study, WBP2 was shown to be upregulated in clinical breast cancer samples. The function of WBP2 in Wnt signaling was investigated through a multi-omics approach includes RNA-Sequencing and iTRAQ-LC-Mass spectrometry analyses. The results showed that WBP2 is a crucial mediator of both the core transcriptional and protein stabilization programs induced by Wnt in breast cancer cells. In addition, AXIN2 was found to be a consistent Wnt/WBP2 target which is essential for cancer cell proliferation and migration. Furthermore, I suggested a regulation axis of WBP2/CSN/JNK/c-Jun/TNIK/Wnt based on the transcriptomic and proteomic effects of WBP2.
dc.language.isoen
dc.subjectBreast cancer, Wnt signaling, WBP2, Transcriptomics, Proteomics
dc.typeThesis
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.supervisorLIM YOON PIN
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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