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Title: Neuropsychiatric lupus and reversible posterior leucoencephalopathy syndrome: A challenging clinical dilemma
Authors: Mak, A. 
Chan, B.P.L.
Yeh, I.B.
Ho, R.C.M. 
Boey, M.L. 
Feng, P.H.
Koh, D.R. 
Ong, B.K.C. 
Keywords: Differentiation
Reversible posterior leucoencephalopathy syndrome
Systemic lupus erythematosus
Treatment strategy
Issue Date: Mar-2008
Citation: Mak, A., Chan, B.P.L., Yeh, I.B., Ho, R.C.M., Boey, M.L., Feng, P.H., Koh, D.R., Ong, B.K.C. (2008-03). Neuropsychiatric lupus and reversible posterior leucoencephalopathy syndrome: A challenging clinical dilemma. Rheumatology 47 (3) : 256-262. ScholarBank@NUS Repository.
Abstract: Reversible posterior leucoencephalopathy syndrome (RPLS) has been increasingly recognized and reported in the literature. While the condition has been well described in patients with acute hypertension, pre-eclampsia, eclampsia, post-transplantation and chemotherapy, RPLS has been increasingly identified in patients with autoimmune diseases such as systemic lupus erythematosus (SLE). Though experience in the diagnosis and management of RPLS in patients with SLE is likely accumulating, few have systematically worked out the strategy to distinguish RPLS from neuropsychiatric SLE (NPSLE) and lupus-related complications of the central nervous system (CNS). Prompt recognition of, and differentiation between, these conditions is essential since their clinical presentations substantially overlap and yet their management strategy and subsequent outcomes can be entirely different. Indeed, inappropriate treatment such as augmentation of immunosuppression may be detrimental to patients with RPLS. A high index of suspicion of RPLS, prompt magnetic resonance imaging of the brain, including diffusion imaging, exclusion of CNS infection and metabolic derangement, a comprehensive medication review accompanied by timely and aggressive control of blood pressure and seizure are keys to successful management of RPLS. Such treatment strategy ensures a very high chance of total neurological recovery in lupus patients with RPLS. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Source Title: Rheumatology
ISSN: 14620324
DOI: 10.1093/rheumatology/kem319
Appears in Collections:Staff Publications

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