Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF00054011
DC FieldValue
dc.titleImplications of intermediate filament protein phosphorylation
dc.contributor.authorKu, N.-O.
dc.contributor.authorLiao, J.
dc.contributor.authorChou, C.-F.
dc.contributor.authorOmary, M.B.
dc.date.accessioned2016-12-13T05:39:40Z
dc.date.available2016-12-13T05:39:40Z
dc.date.issued1996
dc.identifier.citationKu, N.-O., Liao, J., Chou, C.-F., Omary, M.B. (1996). Implications of intermediate filament protein phosphorylation. Cancer and Metastasis Reviews 15 (4) : 429-444. ScholarBank@NUS Repository. https://doi.org/10.1007/BF00054011
dc.identifier.issn01677659
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133058
dc.description.abstractIntermediate filament (IF) proteins, a large family of tissue specific proteins undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural heterogeneity and hence presumed tissue specific functions. Although the function of IF proteins remains poorly understood, several regulatory roles for IF protein phosphorylation have been identified or are emerging. Those roles include filament disassembly and reorganization, solubility, localization within specific cellular domains, association with other cytoplasmic or membrane associated proteins, protection against physiologic stress and mediation of tissue-specific functions. Understanding the mechanistic and functional aspects of IF protein phosphorylation is providing insights not only regarding the function of this modification, but also regarding the function of IF proteins.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/BF00054011
dc.sourceScopus
dc.subjectintermediate filaments
dc.subjectkeratins
dc.subjectphosphorylation
dc.typeReview
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1007/BF00054011
dc.description.sourcetitleCancer and Metastasis Reviews
dc.description.volume15
dc.description.issue4
dc.description.page429-444
dc.description.codenCMRED
dc.identifier.isiutA1996WG50300003
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