Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.onc.1207755
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dc.titleOncogenic potential of the RUNX gene family: 'Overview'
dc.contributor.authorIto, Y.
dc.date.accessioned2016-12-13T05:39:19Z
dc.date.available2016-12-13T05:39:19Z
dc.date.issued2004-05-24
dc.identifier.citationIto, Y. (2004-05-24). Oncogenic potential of the RUNX gene family: 'Overview'. Oncogene 23 (24) : 4198-4208. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.onc.1207755
dc.identifier.issn09509232
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/133028
dc.description.abstractRunt-related (RUNX) gene family is composed of three members, RUNX1/AML1, RUNX2 and RUNX3, and encodes the DNA-binding (α) subunits of the Runt domain transcription factor polyomavirus enhancer-binding protein 2 (PEBP2)/core-binding factor (CBF), which is a heterodimeric transcription factor. RUNX1 is most frequently involved in human acute leukemia. RUNX2 shows oncogenic potential in mouse experimental system. RUNX3 is a strong candidate as a gastric cancer tumor suppressor. The β subunit gene of PEBP2/CBF is also frequently involved in chromosome rearrangements associated with human leukemia. In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.onc.1207755
dc.sourceScopus
dc.subjectDevelopmental regulator
dc.subjectHeterodimeric transcription factor
dc.subjectLeukemia, gastric cancer
dc.subjectPEBP2/CBF
dc.subjectRunt-related (RUNX)
dc.subjectRUNX1/AML1
dc.subjectRUNX2
dc.subjectRUNX3
dc.typeReview
dc.contributor.departmentMEDICINE
dc.description.doi10.1038/sj.onc.1207755
dc.description.sourcetitleOncogene
dc.description.volume23
dc.description.issue24
dc.description.page4198-4208
dc.description.codenONCNE
dc.identifier.isiut000221586000002
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