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https://doi.org/10.1038/sj.onc.1207755
Title: | Oncogenic potential of the RUNX gene family: 'Overview' | Authors: | Ito, Y. | Keywords: | Developmental regulator Heterodimeric transcription factor Leukemia, gastric cancer PEBP2/CBF Runt-related (RUNX) RUNX1/AML1 RUNX2 RUNX3 |
Issue Date: | 24-May-2004 | Citation: | Ito, Y. (2004-05-24). Oncogenic potential of the RUNX gene family: 'Overview'. Oncogene 23 (24) : 4198-4208. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.onc.1207755 | Abstract: | Runt-related (RUNX) gene family is composed of three members, RUNX1/AML1, RUNX2 and RUNX3, and encodes the DNA-binding (α) subunits of the Runt domain transcription factor polyomavirus enhancer-binding protein 2 (PEBP2)/core-binding factor (CBF), which is a heterodimeric transcription factor. RUNX1 is most frequently involved in human acute leukemia. RUNX2 shows oncogenic potential in mouse experimental system. RUNX3 is a strong candidate as a gastric cancer tumor suppressor. The β subunit gene of PEBP2/CBF is also frequently involved in chromosome rearrangements associated with human leukemia. In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family. | Source Title: | Oncogene | URI: | http://scholarbank.nus.edu.sg/handle/10635/133028 | ISSN: | 09509232 | DOI: | 10.1038/sj.onc.1207755 |
Appears in Collections: | Staff Publications |
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