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Title: Oncogenic potential of the RUNX gene family: 'Overview'
Authors: Ito, Y. 
Keywords: Developmental regulator
Heterodimeric transcription factor
Leukemia, gastric cancer
Runt-related (RUNX)
Issue Date: 24-May-2004
Citation: Ito, Y. (2004-05-24). Oncogenic potential of the RUNX gene family: 'Overview'. Oncogene 23 (24) : 4198-4208. ScholarBank@NUS Repository.
Abstract: Runt-related (RUNX) gene family is composed of three members, RUNX1/AML1, RUNX2 and RUNX3, and encodes the DNA-binding (α) subunits of the Runt domain transcription factor polyomavirus enhancer-binding protein 2 (PEBP2)/core-binding factor (CBF), which is a heterodimeric transcription factor. RUNX1 is most frequently involved in human acute leukemia. RUNX2 shows oncogenic potential in mouse experimental system. RUNX3 is a strong candidate as a gastric cancer tumor suppressor. The β subunit gene of PEBP2/CBF is also frequently involved in chromosome rearrangements associated with human leukemia. In this Overview, I will summarize how this growing field has been formed and what are the challenging new frontiers for better understanding of the oncogenic potential of this gene family.
Source Title: Oncogene
ISSN: 09509232
DOI: 10.1038/sj.onc.1207755
Appears in Collections:Staff Publications

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