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Title: Peripapillary Retinal Nerve Fiber Layer Thickness Variations with Myopia
Authors: Hoh, S.-T.
Lim, M.C.C.
Seah, S.K.L.
Lim, A.T.H.
Chew, S.-J.
Foster, P.J.
Aung, T. 
Issue Date: May-2006
Citation: Hoh, S.-T., Lim, M.C.C., Seah, S.K.L., Lim, A.T.H., Chew, S.-J., Foster, P.J., Aung, T. (2006-05). Peripapillary Retinal Nerve Fiber Layer Thickness Variations with Myopia. Ophthalmology 113 (5) : 773-777. ScholarBank@NUS Repository.
Abstract: Purpose: To determine the relationship between peripapillary retinal nerve fiber layer (RNFL) thickness and myopia using optical coherence tomography (OCT). Design: Prospective observational case series. Methods: One hundred thirty-two young males with myopia (spherical equivalent [SE], -0.50 to -14.25 diopters) underwent ophthalmic examination of one randomly selected eye. Optical coherence tomography (OCT-1, version 4.1) was performed by a single operator using circular scans concentric with the optic disc with scan diameters of 3.40 mm, 4.50 mm, and 1.75 × vertical disc diameter (VDD). For each scan diameter, mean peripapillary RNFL thickness was calculated. Statistical analysis comprised repeated-measurements analysis and Pearson correlation. Results: Mean peripapillary RNFL thickness did not correlate with SE for the 3.40-mm (r = -0.11, P = 0.22), 4.50-mm (r = -0.103, P = 0.24), or 1.75×VDD (r = -0.08, P = 0.36) OCT scan diameters. Neither did mean peripapillary RNFL thickness correlate with axial length for the 3.40-mm (r = -0.04, P = 0.62), 4.50-mm (r = 0.03, P = 0.75), or 1.75×VDD (r = -0.02, P = 0.78) scan diameters. Mean peripapillary RNFL thicknesses for the 3.40-mm, 4.50-mm, and 1.75×VDD scans were 101.1±8.2 μm (95% confidence interval [CI], 99.4-102.8), 78.9±8.2 μm (95% CI, 77.5-80.3), and 97.5±10.9 μm (95% CI, 95.6-99.4), respectively. Conclusions: Mean peripapillary RNFL thickness did not vary with myopic SE or axial length for any OCT scan diameter investigated. Retinal NFL thickness measurements may be a useful parameter to assess and monitor glaucoma damage in myopic subjects. © 2006 American Academy of Ophthalmology.
Source Title: Ophthalmology
ISSN: 01616420
DOI: 10.1016/j.ophtha.2006.01.058
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