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Title: Positive association between plasma homocysteine level and chronic kidney disease
Authors: Shankar, A. 
Wang, J.J.
Chua, B.
Rochtchina, E.
Flood, V.
Mitchell, P.
Keywords: Blue Mountains Eye Study
Chronic kidney disease
Plasma homocysteine
Issue Date: Feb-2008
Citation: Shankar, A., Wang, J.J., Chua, B., Rochtchina, E., Flood, V., Mitchell, P. (2008-02). Positive association between plasma homocysteine level and chronic kidney disease. Kidney and Blood Pressure Research 31 (1) : 55-62. ScholarBank@NUS Repository.
Abstract: Background: Increasing experimental evidence, including recently developed animal models, supports a role for homocysteine in the development of chronic kidney disease (CKD). However, relatively few clinical/epidemiological studies have examined this hypothesis in humans. We examined the relationship between plasma homocysteine level and CKD in a population-based study of older Australians. Methods: Community-based study (1992-1994) among 2,609 individuals (58.6% women), aged 49-98 years, free of clinical cardiovascular disease in the Blue Mountains region, west of Sydney, Australia. The main outcome-of-interest was CKD (n = 461), defined as estimated glomerular filtration rate of 14 μmol/l) to quartile 1 (≤9 μmol/l) was 10.44 (6.99-15.60), p-trend
Source Title: Kidney and Blood Pressure Research
ISSN: 14204096
DOI: 10.1159/000114300
Appears in Collections:Staff Publications

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