Please use this identifier to cite or link to this item:
https://doi.org/10.1006/excr.2002.5579
DC Field | Value | |
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dc.title | Furrow-specific endocytosis during cytokinesis of zebrafish blastomeres | |
dc.contributor.author | Feng, B. | |
dc.contributor.author | Schwarz, H. | |
dc.contributor.author | Jesuthasan, S. | |
dc.date.accessioned | 2016-12-13T05:36:06Z | |
dc.date.available | 2016-12-13T05:36:06Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Feng, B., Schwarz, H., Jesuthasan, S. (2002). Furrow-specific endocytosis during cytokinesis of zebrafish blastomeres. Experimental Cell Research 279 (1) : 14-20. ScholarBank@NUS Repository. https://doi.org/10.1006/excr.2002.5579 | |
dc.identifier.issn | 00144827 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/132751 | |
dc.description.abstract | Mutations affecting endocytosis, such as those in clathrin and dynamin, unexpectedly cause defects in cytokinesis in a number of organisms. To explore the relationship between endocytosis and cytokinesis, we used the relatively large cells of the transparent zebrafish embryo. Using fluorescent markers for fluid-phase as well as plasma membrane uptake, we demonstrate that cytokinesis involves furrow-specific endocytosis. Clathrin-coated pits are visible near the furrow in ultrathin sections, while immunolabeling demonstrates that clathrin and caveolin are localized to the cleavage furrow. Hence, it is likely that both clathrin- and caveolae-mediated endocytosis occurs at the furrow during cytokinesis. Dynamin II is also localized to the furrow and may mediate furrow-specific endocytosis. Treatment of embryos with chlorpromazine or with methyl-β-cyclodextrin, both of which inhibit endocytosis, prevents the normal completion of cytokinesis. These data suggest that furrow-specific endocytosis is an integral part of cytokinesis. © 2002 Elsevier Science (USA). | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1006/excr.2002.5579 | |
dc.source | Scopus | |
dc.subject | Caveolin | |
dc.subject | Clathrin | |
dc.subject | Cytokinesis | |
dc.subject | Danio rerio | |
dc.subject | Endocytosis | |
dc.type | Article | |
dc.contributor.department | INSTITUTE OF MOLECULAR AGROBIOLOGY | |
dc.description.doi | 10.1006/excr.2002.5579 | |
dc.description.sourcetitle | Experimental Cell Research | |
dc.description.volume | 279 | |
dc.description.issue | 1 | |
dc.description.page | 14-20 | |
dc.description.coden | ECREA | |
dc.identifier.isiut | 000177968800002 | |
Appears in Collections: | Staff Publications |
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