Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/13271
DC Field | Value | |
---|---|---|
dc.title | Design of macromolecular and supramolecular architecture as functional materials | |
dc.contributor.author | LIU KERH LI | |
dc.date.accessioned | 2010-04-08T10:31:31Z | |
dc.date.available | 2010-04-08T10:31:31Z | |
dc.date.issued | 2008-05-21 | |
dc.identifier.citation | LIU KERH LI (2008-05-21). Design of macromolecular and supramolecular architecture as functional materials. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/13271 | |
dc.description.abstract | Amphiphilic block copolymers with poly(3-hydroxybutyrate) (PHB) and poly(ethylene glycol) (PEG) segments of different macromolecular architectures were synthesized and thoroughly characterized. With different macromolecular architectures, various self-assembly behaviors leading to supramolecular architectures such as thin films with lamellar morphology, spherical micelle of core-shell structure and physically cross-linked hydrogel were observed. Harnessing their amphiphilic nature, good biocompatibility and self-assembly property, the block copolymers were accessed for their potential biomedical applications. Multiblock PHB-alt-PEGs imparted tremendous multidimensional enhancements to PHBV through blending and hence render the blends good biomaterials candidate as tissue engineering scaffold. Micelles obtained from PHB-PEG-PHB triblock copolymers have good potential as nanocarrier in drug delivery systems for their stability towards dilution and temperature fluctuations. Hydrogels resulted from PHB-PEG-PHB/α-cyclodextrin polypseudorotaxanes demonstrated good strength and maybe used as depot in controlled drug release applications. This study also exemplifies the bottom-up approach towards biodegradable nanostructured materials with PHB-based materials. | |
dc.language.iso | en | |
dc.subject | Self-assemby, Block copolymer, Poly(3-hydroxybutyrate), Poly(ethylene glycol), Cyclodextrins, Host-guest chemistry | |
dc.type | Thesis | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.supervisor | GOH SUAT HONG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
00Chap.pdf | 172.87 kB | Adobe PDF | OPEN | None | View/Download | |
01Chap.pdf | 94.36 kB | Adobe PDF | OPEN | None | View/Download | |
02Chap.pdf | 1.57 MB | Adobe PDF | OPEN | None | View/Download | |
03Chap.pdf | 457.51 kB | Adobe PDF | OPEN | None | View/Download | |
04Chap.pdf | 461.24 kB | Adobe PDF | OPEN | None | View/Download | |
05Chap.pdf | 938.78 kB | Adobe PDF | OPEN | None | View/Download | |
06Chap.pdf | 560.17 kB | Adobe PDF | OPEN | None | View/Download | |
07Chap.pdf | 76.97 kB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.