Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/132703
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dc.titleHLA haplotype sharing in affected siblings in multiple case Chinese families with thyrotoxicosis
dc.contributor.authorChan, S.H.
dc.contributor.authorYeo, P.P.B.
dc.contributor.authorCheah, J.S.
dc.contributor.authorLim, P.
dc.date.accessioned2016-12-13T05:35:32Z
dc.date.available2016-12-13T05:35:32Z
dc.date.issued1980
dc.identifier.citationChan, S.H., Yeo, P.P.B., Cheah, J.S., Lim, P. (1980). HLA haplotype sharing in affected siblings in multiple case Chinese families with thyrotoxicosis. Tissue Antigens 16 (3) : 258-259. ScholarBank@NUS Repository.
dc.identifier.issn00012815
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132703
dc.description.abstractHLA associations in unrelated Chinese thyrotoxicosis have been reported. The main association is with BW46 (RR = 3.74). However, the joint occurrences of BW46 and B40 or BW46 and B13 were significantly more frequent in thyrotoxic patients than controls, giving rise to higher RR's of 8.74 and 5.88, respectively. These findings suggested the involvement of both sixth chromosomes in the pathogenesis of this disease. We also had an opportunity to study 12 multiple case Chinese thyrotoxic families in which there were affected sibling pairs and the HLA results supported the hypothesis of the involvement of both haplotypes.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentWHO IMMUNOLOGY RESEARCH & TRAINING CTR
dc.description.sourcetitleTissue Antigens
dc.description.volume16
dc.description.issue3
dc.description.page258-259
dc.description.codenTSANA
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

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