Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.emboj.7600371
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dc.titleLats2/Kpm is required for embryonic development, proliferation control and genomic integrity
dc.contributor.authorMcPherson, J.P.
dc.contributor.authorTamblyn, L.
dc.contributor.authorElia, A.
dc.contributor.authorMigon, E.
dc.contributor.authorShehabeldin, A.
dc.contributor.authorMatysiak-Zablocki, E.
dc.contributor.authorLemmers, B.
dc.contributor.authorSalmena, L.
dc.contributor.authorHakem, A.
dc.contributor.authorFish, J.
dc.contributor.authorKassam, F.
dc.contributor.authorSquire, J.
dc.contributor.authorBruneau, B.G.
dc.contributor.authorHande, M.P.
dc.contributor.authorHakem, R.
dc.date.accessioned2016-12-13T05:35:00Z
dc.date.available2016-12-13T05:35:00Z
dc.date.issued2004-09-15
dc.identifier.citationMcPherson, J.P., Tamblyn, L., Elia, A., Migon, E., Shehabeldin, A., Matysiak-Zablocki, E., Lemmers, B., Salmena, L., Hakem, A., Fish, J., Kassam, F., Squire, J., Bruneau, B.G., Hande, M.P., Hakem, R. (2004-09-15). Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO Journal 23 (18) : 3677-3688. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.emboj.7600371
dc.identifier.issn02614189
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132658
dc.description.abstractThe Drosophila melanogaster warts/lats tumour suppressor has two mammalian counterparts LATS1/Warts-1 and LATS2/Kpm. Here, we show that mammalian Lats orthologues exhibit distinct expression profiles according to germ cell layer origin. Lats2-/- embryos show overgrowth in restricted tissues of mesodermal lineage; however, lethality ultimately ensues on or before embryonic day 12.5 preceded by defective proliferation. Lats2-/- mouse embryonic fibroblasts (MEFs) acquire growth advantages and display a profound defect in contact inhibition of growth, yet exhibit defective cytokinesis. Lats2-/- embryos and MEFs display centrosome amplification and genomic instability. Lats2 localizes to centrosomes and overexpression of Lats2 suppresses centrosome overduplication induced in wild-type MEFs and reverses centrosome amplification inherent in Lats2-/- MEFs. These findings indicate an essential role of Lats2 in the integrity of processes that govern centrosome duplication, maintenance of mitotic fidelity and genomic stability.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/sj.emboj.7600371
dc.sourceScopus
dc.subjectCentrosome
dc.subjectEmbryonic lethality
dc.subjectGenomic instability
dc.subjectKpm
dc.subjectLats2
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1038/sj.emboj.7600371
dc.description.sourcetitleEMBO Journal
dc.description.volume23
dc.description.issue18
dc.description.page3677-3688
dc.description.codenEMJOD
dc.identifier.isiut000224409100010
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