Polymorphisms of alpha-1-acid (orosomucoid), alpha-2-HS- glycoproteins and alpha-1-B among the Parsis of India

Abstract

Genetic polymorphisms of plasma α1-acid glycoprotein (orosomucoid, ORM), α2-HS-glycoprotein (A2HS) and α1-B-glycoprotein (α1B) were studied in a group of Parsis in Bombay, India. The frequencies of ORM1(*)1, ORM1(*)2 and 0RM1(*)3 were found to be 0.636, 0.356 and 0.008, respectively. A2HS(*)1, A2HS(*)2 and A2HS(*)3 frequencies were 0.855, 0.135 and 0.010, while the frequencies of A1B(*)1 and A1B(*)2 were 0.881 and 0.119, respectively. The phenotype distribution at all three loci was at Hardy-Weinberg equilibrium. The ORM2 locus was monomorphic in the Parsis.