Please use this identifier to cite or link to this item:
DC FieldValue
dc.titlePlasminogen activators t-PA, u-PA and its inhibitor (PAI) in normal males and females
dc.contributor.authorKoh, S.C.L.
dc.contributor.authorYuen, R.
dc.contributor.authorViegas, O.A.C.
dc.contributor.authorChua, S.E.
dc.contributor.authorNg, B.L.
dc.contributor.authorSen, D.K.
dc.contributor.authorRatnam, S.S.
dc.identifier.citationKoh, S.C.L., Yuen, R., Viegas, O.A.C., Chua, S.E., Ng, B.L., Sen, D.K., Ratnam, S.S. (1991). Plasminogen activators t-PA, u-PA and its inhibitor (PAI) in normal males and females. Thrombosis and Haemostasis 66 (5) : 581-585. ScholarBank@NUS Repository.
dc.description.abstractWe determined the plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI) activity and their antigen levels including urokinase plasminogen activator (u-PA) in 33 male and 27 female normal subjects. Males had mean t-PA activity of 0.50 iu/ml which was significantly lower (p < 0.01) than the females 0.64 iu/ml. Males had higher (p < 0.001) mean PAI activity (15.5 AU/ml) as compared to females 10.3 AU/ml. The respective mean levels of t-PA and PAI antigen were significantly higher (p < 0.01) in males (8.1 ng/ml and 17.6 ng/ml) than in females (6.2 ng/ml and 12.1 ng/ml). The mean u-PA level in males was 1.54 ng/ml which was significantly higher (p < 0.01) than in females with 1.02 ng/ml. In post-venous occlusion studies, females had a greater mean response of 8.6 fold in t-PA activity as compared to males with a mean of 4.5 fold increase. The mean t-PA antigen response in males was 2.0 fold increase as compared to 2.6 fold increase in the females. No significant responses were seen in both sexes in either PAI activity or antigen levels when compared with the resting state. In zymography studies, free t-PA, its inhibitor complexes and u-PA were demonstrated in the euglobulin fractions of stored plasma. This study demonstrates that significant differences in t-PA, u-PA and PAI exist between male and female subjects which should be taken into account when determining their levels in clinical conditions.
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.sourcetitleThrombosis and Haemostasis
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Feb 2, 2023

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.