Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0010-7824(96)00276-4
Title: | Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants | Authors: | Sivin, I. Lähteenmäki, P. Ranta, S. Darney, P. Klaisle, C. Wan, L. Mishell Jr., D.R. Lacarra, M. Viegas, O.A.C. Bilhareus, P. Koetsawang, S. Piya-Anant, M. Diaz, S. Pavez, M. Alvarez, F. Brache, V. LaGuardia, K. Nash, H. Stern, J. |
Keywords: | contraception implants levonorgestrel concentrations rod implants |
Issue Date: | Feb-1997 | Citation: | Sivin, I., Lähteenmäki, P., Ranta, S., Darney, P., Klaisle, C., Wan, L., Mishell Jr., D.R., Lacarra, M., Viegas, O.A.C., Bilhareus, P., Koetsawang, S., Piya-Anant, M., Diaz, S., Pavez, M., Alvarez, F., Brache, V., LaGuardia, K., Nash, H., Stern, J. (1997-02). Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants. Contraception 55 (2) : 81-85. ScholarBank@NUS Repository. https://doi.org/10.1016/S0010-7824(96)00276-4 | Abstract: | In a three-year randomized trial that included 398 women, blood samples were collected for the purpose of assaying levonorgestrel concentrations in women using a new two-rod contraceptive implant system or an earlier implant formulation, Norplant®-2 implants. Sample collection was at 1, 3, 6, 9, and 12 months after placement and semiannually thereafter through three years. Resulting assays and analyses showed that levonorgestrel concentrations of each implant formulation decreased significantly with time after placement, with increasing body weight, and with ponderal index. In the third year, several measures indicated that concentrations of the contraceptive drug were higher in women using the LNG ROD implants than in users of the original formulation. No pregnancies occurred among women in either group in the three years. This study provides evidence that the minimum levonorgestrel concentration needed to protect against pregnancy is below 200 pg/ml, and possibly is below 175 pg/ml. | Source Title: | Contraception | URI: | http://scholarbank.nus.edu.sg/handle/10635/132583 | ISSN: | 00107824 | DOI: | 10.1016/S0010-7824(96)00276-4 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.