Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.2910630211
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dc.titleHLA-A2 allelic microvariants in nasopharyngeal carcinoma
dc.contributor.authorRen, E.C.
dc.contributor.authorLaw, G.C.T.
dc.contributor.authorChan, S.H.
dc.date.accessioned2016-12-13T05:33:48Z
dc.date.available2016-12-13T05:33:48Z
dc.date.issued1995
dc.identifier.citationRen, E.C., Law, G.C.T., Chan, S.H. (1995). HLA-A2 allelic microvariants in nasopharyngeal carcinoma. International Journal of Cancer 63 (2) : 213-215. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.2910630211
dc.identifier.issn00207136
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132555
dc.description.abstractHLA-A2 positive nasopharyngeal carcinoma (NPC; n = 38) and normal control (n = 51) populations were analysed by high-resolution oligotyping to identify A2 allelic microvariants. Within the control group, A*0207 was found to be the most common allele, accounting for 50% of the A2 frequency in normals. In contrast, this allele was found to be present in only 23% of NPC cases, suggesting a protective effect. Of these 9 NPC patients with A*0207, all were associated with B46, unlike in the control group, where it can be found associated with non-B46 antigens. Another allele, A*0201, which was thought to be protective against NPC was in fact present in 39.5% of NPC patients, more than twice the frequency in controls. These data confirm that A*0201 is not, a protective allele for NPC, and other factors such as the A*0207, non-B46 haplotype are of greater importance.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ijc.2910630211
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.contributor.departmentWHO IMMUNOLOGY RESEARCH & TRAINING CTR
dc.description.doi10.1002/ijc.2910630211
dc.description.sourcetitleInternational Journal of Cancer
dc.description.volume63
dc.description.issue2
dc.description.page213-215
dc.description.codenIJCNA
dc.identifier.isiutA1995TB40700010
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