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|Title:||Immunogenetics of nasopharyngeal carcinoma. Position in 1980||Authors:||Chan, S.H.||Issue Date:||1980||Citation:||Chan, S.H. (1980). Immunogenetics of nasopharyngeal carcinoma. Position in 1980. Annals of the Academy of Medicine Singapore 9 (3) : 296-299. ScholarBank@NUS Repository.||Abstract:||The HLA profile of 313 newly diagnosed Chinese NPC patients was compared to that of 330 normal Chinese subjects. A2 Bw46 and Aw19/B B17 were associated with increased risks of developing NPC whereas A11 was associated with a decreased risk. A2 Bw46 was confined to older onset patients whereas Aw19/B B17 was associated with NPC patients of all ages but particularly with younger patients. The Aw19/B B17 haplotype was also associated with poor survival. A DR blank was strongly associated with NPC giving a relative risk of 26.5. In Malay NPC the HLA associations were Aw19/B B17 and A9 B18 and in Kadazan NPC, the association was with A9. Possible mechanisms of the HLA association were discussed.||Source Title:||Annals of the Academy of Medicine Singapore||URI:||http://scholarbank.nus.edu.sg/handle/10635/132541||ISSN:||03044602|
|Appears in Collections:||Staff Publications|
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