Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/132528
DC Field | Value | |
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dc.title | Hepatitis B vaccination: Half dose recombinant DNA hepatitis B vaccine (B-Hepavac II) is as immunogenic as the full recommended dose in healthy adults | |
dc.contributor.author | Guan, R. | |
dc.contributor.author | Yap, I. | |
dc.contributor.author | Tay, H.H. | |
dc.date.accessioned | 2016-12-13T05:33:29Z | |
dc.date.available | 2016-12-13T05:33:29Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | Guan, R., Yap, I., Tay, H.H. (1991). Hepatitis B vaccination: Half dose recombinant DNA hepatitis B vaccine (B-Hepavac II) is as immunogenic as the full recommended dose in healthy adults. Journal of Gastroenterology and Hepatology 6 (4) : 374-376. ScholarBank@NUS Repository. | |
dc.identifier.issn | 08159319 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/132528 | |
dc.description.abstract | Sixty-seven healthy adult volunteers aged 20-40 years with no previous exposure to hepatitis B virus were randomized to receive either a 10 μg or 5 μg dose of recombinant DNA hepatitis B (HB) vaccine (B-Hepavac II) intramuscularly at 0, 1 and 6 months. Two months after the third injection 100% of subjects had seroconverted: 97% of the 10 μg group and 91% of the 5 μg group had antibody to HB surface antigen (anti-HBs) levels greater than 10 iu/L. The geometric mean titres (GMT) of anti-HBs levels at this time were 891 iu/L in the 10 μg dose group and 923 iu/L in the 5 μg dose group. These differences were not significant. Adverse effects included fever and mild pain at the injection site. The reduced dose of 5 μg was as effective as the standard 10 μg dose. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.sourcetitle | Journal of Gastroenterology and Hepatology | |
dc.description.volume | 6 | |
dc.description.issue | 4 | |
dc.description.page | 374-376 | |
dc.description.coden | JGHEE | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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