Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/132501
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dc.titleLight and electron microscopic demonstration of some lysosomal enzymes in the amoeboid microglia in neonatal rat brain
dc.contributor.authorLing, E.A.
dc.date.accessioned2016-12-13T05:33:10Z
dc.date.available2016-12-13T05:33:10Z
dc.date.issued1977
dc.identifier.citationLing, E.A. (1977). Light and electron microscopic demonstration of some lysosomal enzymes in the amoeboid microglia in neonatal rat brain. Journal of Anatomy 123 (3) : 637-648. ScholarBank@NUS Repository.
dc.identifier.issn00218782
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132501
dc.description.abstractA cytochemical study of the ameboid microglial cells in the brain of the neonatal rat showed that these vacuolated cells exhibit strong acid phosphatase, aryl sulfatase and adenosine triphosphatase (ATPase) activities. Endogenous peroxidase, however, was not present. With the electron microscope the reaction product of acid phosphatase was found to be localized in some of the Golgi cisternae, in the majority of the electron dense secretory granules, and in an occasional long tubular profile. The secretory granules were not uniformly stained for this enzyme, some showing only a focal reaction or none at all. The distribution of the activity of aryl sulfatase corresponded to that of acid phosphatase except that all the granules appeared to contain the former enzyme. With the light microscope the ameboid microglial cells were intensely stained for ATPase. From these observations it is concluded that ameboid microglia are active phagocytes and their enzyme rich secretory granules are lysosomes.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.sourcetitleJournal of Anatomy
dc.description.volume123
dc.description.issue3
dc.description.page637-648
dc.description.codenJOANA
dc.identifier.isiutNOT_IN_WOS
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