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Title: The role of respiratory proteins in innate immunity
Keywords: hemocyanin, hemoglobin, reactive oxygen species, microbial proteases, PAMPs, innate immunity
Issue Date: 22-Apr-2008
Citation: JIANG NAXIN (2008-04-22). The role of respiratory proteins in innate immunity. ScholarBank@NUS Repository.
Abstract: Hemoglobin (Hb) and hemocyanin (HMC) are oligomeric respiratory proteins found in the vertebrates and invertebrates, respectively. Recent studies have revealed that hemocyanin and hemoglobin can generate cytotoxic ROS via prophenoloxidase (PPO) and pseudoperoxidase activity, respectively. In this study, we found that the respiratory proteins of both the horseshoe crab and human were directly activated by microbial proteases and were enhanced by pathogen-associated molecular patterns, resulting in the production of more reactive oxygen species. Hemolytic virulent pathogens, which produce proteases as invasive factors, are more susceptible to this killing mechanism. In contrast to previous work, this study has revealed a novel extracellular defense mechanism independent of host immune cells. This b shortcutb antimicrobial strategy represents a fundamental and universal mode of immunosurveillance, which has been in existence since before the split of protostomes and deuterostomes and still persists today.
Appears in Collections:Ph.D Theses (Open)

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