Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/132271
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dc.titleFABRICATION AND CHARACTERIZATION OF POLYCAPROLACTONE SCAFFOLDS VIA ELECTROHYDRODYNAMIC JET 3D PRINTING FOR TENDON TISSUE REGENERATION
dc.contributor.authorWU YANG
dc.date.accessioned2016-12-12T18:00:19Z
dc.date.available2016-12-12T18:00:19Z
dc.date.issued2016-08-08
dc.identifier.citationWU YANG (2016-08-08). FABRICATION AND CHARACTERIZATION OF POLYCAPROLACTONE SCAFFOLDS VIA ELECTROHYDRODYNAMIC JET 3D PRINTING FOR TENDON TISSUE REGENERATION. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132271
dc.description.abstractTissue engineering has showed promising results in restoring diseased tendon tissue functions. In this thesis, a hybrid three-dimensional (3D) porous scaffold comprising an outer portion rolled from an electrohydrodynamic jet printed poly(ɛ-caprolactone) (PCL) fiber mesh, and an inner portion fabricated from uniaxial stretching of a heat-sealed PCL tube, was developed for tendon tissue engineering (TE) application. The 3D tendon scaffold included micrometer-scale fibrous bundles, interconnected spacing and geometric anisotropy along the scaffold length. In addition, the as-fabricated scaffold exhibited comparable mechanical properties to those of the human patellar tendon. Also, the scaffold degradation exhibited consistency between the weight loss and the decline of mechanical properties. Compared to the traditional electrospun scaffolds, human tenocytes cultured in the tendon scaffolds showed up-regulated cellular metabolism, cell alignment, and tendon-related gene expression. These results demonstrated the potential of mechanically-enhanced 3D fibrous scaffold for applications in tendon TE, with desired cell alignment and functional differentiation.
dc.language.isoen
dc.subject3D printing, electrohydrodynamic jet printing, tendon tissue engineering, 3D scaffold, cell alignment, contact guidance
dc.typeThesis
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.supervisorFUH YING HSI, JERRY
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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