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https://scholarbank.nus.edu.sg/handle/10635/132136
DC Field | Value | |
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dc.title | MILD NUTRIENT STARVATION TRIGGERS THE DEVELOPMENT OF A SMALL-CELL SURVIVAL MORPHOTYPE IN MYCOBACTERIA | |
dc.contributor.author | MULU WU | |
dc.date.accessioned | 2016-11-30T18:00:52Z | |
dc.date.available | 2016-11-30T18:00:52Z | |
dc.date.issued | 2016-06-29 | |
dc.identifier.citation | MULU WU (2016-06-29). MILD NUTRIENT STARVATION TRIGGERS THE DEVELOPMENT OF A SMALL-CELL SURVIVAL MORPHOTYPE IN MYCOBACTERIA. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/132136 | |
dc.description.abstract | Mycobacteria, generally believed to be non-differentiating, are well known to survive shock starvation in saline for extended periods of time in a non-replicating state without any apparent morphological changes. Here we uncover that mycobacteria actually harbor a novel, starvation-induced differentiation program in which first septated multi-nucleoided cells are generated. Under zero-nutrient conditions, bacteria terminate development at this stage as large resting cells (LARCs). In the presence of traces of nutrient, these multi-nucleoided cells continue differentiation to mono-nucleoided small resting cells (SMRCs). Both SMRCs and LARCs exhibited extreme antibiotic tolerance. SMRCs showed increased long-term starvation survival, which was associated with the presence of lipid inclusion bodies. Interestingly, the stringent response regulator RelA appeared to play the role of cellular differentiation other than a starvation survival factor in this process. | |
dc.language.iso | en | |
dc.subject | mycobacteria, nutrient starvation, bacterial differentiation, SMRC, LARC, non-replicating | |
dc.type | Thesis | |
dc.contributor.department | MICROBIOLOGY & IMMUNOLOGY | |
dc.contributor.supervisor | THOMAS DICK | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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WU Mulu_PhD Thesis.pdf | 14.59 MB | Adobe PDF | OPEN | None | View/Download |
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