Please use this identifier to cite or link to this item:
Title: Ultrastructural changes in the gracile nucleus of alloxan-induced diabetic rats
Authors: Tay, S.S.W. 
Wong, W.C.
Issue Date: 1990
Citation: Tay, S.S.W., Wong, W.C. (1990). Ultrastructural changes in the gracile nucleus of alloxan-induced diabetic rats. Acta Anatomica 139 (4) : 367-373. ScholarBank@NUS Repository.
Abstract: The present study reports ultrastructural changes in the gracile nucleus of male Wistar rats after alloxan-induced diabetes. During the acute phase (3-7 days) degenerating electron-dense dendrites and axon terminals were dispersed in the neuropil. Degenerating dendrites were characterized by an electron-dense cytoplasm, swollen mitochondria, dilated endoplasmic reticulum and randomized ribosomes. Degenerating axon terminals were characterized by an electron-dense cytoplasm and clustering of small spherical agranular vesicles. Degenerating axon terminals may form the central element or part of a synaptic glomerulus. Macrophages were present in the neuropil and in the process of engulfing neuronal elements. During the medium phase (1-6 months), most of the degenerating dendrites and axon terminals had been engulfed or removed by macrophages. During the late phase (9-12 months), a second wave of degeneration occurred in the gracile nucleus, similar to the acute phase.
Source Title: Acta Anatomica
ISSN: 00015180
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on May 22, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.