Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131849
DC FieldValue
dc.titleUltrastructure of the cuneate nucleus in the streptozotocin-induced diabetric rat
dc.contributor.authorDheen, S.T.
dc.contributor.authorTay, S.S.W.
dc.contributor.authorWong, W.C.
dc.date.accessioned2016-11-29T02:49:25Z
dc.date.available2016-11-29T02:49:25Z
dc.date.issued1994
dc.identifier.citationDheen, S.T., Tay, S.S.W., Wong, W.C. (1994). Ultrastructure of the cuneate nucleus in the streptozotocin-induced diabetric rat. Journal of Brain Research 35 (2) : 253-262. ScholarBank@NUS Repository.
dc.identifier.issn09448160
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131849
dc.description.abstractThis study describes the ultrastructural changes in the cuneate nucleus of the streptozotocin-induced diabetic rats at 3, 6, 9 and 12 months post-induction. At 3 and 6 months post-diabetes, a marked atrophy was observed in the myelinated axons. The atrophic axons showed delamination of myelin sheath, tightly arranged lamellar whorls, vesicular elements and degenerating debris within the electron-lucent axoplasm. At 9 and 12 months post-diabetes, a variety of dystrophic and degenerating axonal profiles and dendrites were seen in neuropil. The dystrophic axonal profiles containing tubulovesicular elements, slit-like clefts, vacuoles, swollen mitochondria, membranous and multigranular bodies appeared to be hypertrophied. The degenerating axon terminals contained swollen mitochondria and clustered spherical agranular vesicles in their electron-dense granular axoplasm. The degenerating dendrites were identified by the presence of swollen mitochondria, dilated ER in the electron-dense cytoplasm and they often formed the synaptic glomeruli with central axon terminals. Macrophages containing lipid bodies and electron-dense elements in their cytoplasm were in the process of phagocytosis. In all the time intervals studied, the somata appeared to be normal and the number of dystrophic and degenerating axonal profiles in the cuneate nucleus of diabetic rats was significantly increased in comparison with age-matched saline injected control rats.
dc.sourceScopus
dc.subjectcuneate nucleus
dc.subjectdiabetes mellitus
dc.subjectrat
dc.subjectstreptozotocin
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.sourcetitleJournal of Brain Research
dc.description.volume35
dc.description.issue2
dc.description.page253-262
dc.description.codenJBRRE
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Page view(s)

43
checked on Feb 2, 2023

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.