Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131837
DC FieldValue
dc.titleTussive effect of a fentanyl bolus
dc.contributor.authorPhua, W.T.
dc.contributor.authorTeh, B.T.
dc.contributor.authorJong, W.
dc.contributor.authorLee, T.L.
dc.contributor.authorTweed, W.A.
dc.date.accessioned2016-11-29T02:49:17Z
dc.date.available2016-11-29T02:49:17Z
dc.date.issued1991
dc.identifier.citationPhua, W.T., Teh, B.T., Jong, W., Lee, T.L., Tweed, W.A. (1991). Tussive effect of a fentanyl bolus. Canadian Journal of Anaesthesia 38 (3) : 330-334. ScholarBank@NUS Repository.
dc.identifier.issn0832610X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131837
dc.description.abstractThe aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl. The study sample was 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. The first 100 were randomly allocated to receive 1.5 μg·kg -1 fentanyl via a peripheral venous cannula (Group 1), or an equivalent volume of saline (Group 2). Twenty-eight per cent of patients who received fentanyl, but none given saline, coughed within one minute (P < 0.0001). The second 150 patients were then randomly assigned to three equal pretreatment groups. Group 3 received 0.01 mg·kg -1 atropine iv one minute before fentanyl. Groups 4 and 5 received 0.2 mg·kg -1 morphine im, and 7.5 mg midazolam po, respectively, one hour before fentanyl. Thirty per cent of patients in Group 3, 6% in Group 4, and 40% in Group 5, had a cough response to fentanyl. Fentanyl, when given through a peripheral cannula, provoked cough in a considerable proportion of patients. This was not altered by premedication with atropine or midazolam, but was reduced after morphine (P < 0.01). Coughing upon induction of anaesthesia is undesirable in some patients, and stimulation of cough by fentanyl in unpremedicated patients may be of clinical importance.
dc.sourceScopus
dc.subjectAnalgesics
dc.subjectCough
dc.subjectFentanyl
dc.typeArticle
dc.contributor.departmentANAESTHESIA
dc.description.sourcetitleCanadian Journal of Anaesthesia
dc.description.volume38
dc.description.issue3
dc.description.page330-334
dc.description.codenCJOAE
dc.identifier.isiutNOT_IN_WOS
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