Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/131834
DC FieldValue
dc.titleSingle vital capacity inhalational anesthetic induction in adults - Isoflurane vs sevoflurane
dc.contributor.authorLian Kah Ti
dc.contributor.authorHwee Leng Pua
dc.contributor.authorTat Leang Lee
dc.date.accessioned2016-11-29T02:49:14Z
dc.date.available2016-11-29T02:49:14Z
dc.date.issued1998
dc.identifier.citationLian Kah Ti, Hwee Leng Pua, Tat Leang Lee (1998). Single vital capacity inhalational anesthetic induction in adults - Isoflurane vs sevoflurane. Canadian Journal of Anaesthesia 45 (10) : 949-953. ScholarBank@NUS Repository.
dc.identifier.issn0832610X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131834
dc.description.abstractPurpose: To evaluate whether isoflurane is as suitable as sevoflurane for the single vital capacity breath (VCB) method of inhalational induction in patients premedicated with midazolam. Methods: A randomised, controlled, double-blind study involving 67 ASA I-II patients aged between 18-50 yr undergoing elective surgery under general anaesthesia. All participants received premedication with 0.03 mg·kg-1 midazolam iv. Using a primed circle absorber circuit, inhalational induction of anaesthesia was performed with the single VCB method using either isoflurane 3.5% or sevoflurane 7.5% in nitrous oxide 67% in oxygen, representing approximately equivalent MAC- multiples of 3.6 MAC. Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction. Results: With the single VCB method, sevoflurane produced a faster (45 ± 21 vs 71 ± 22 sec, P < 0.01), more successful (100% vs 75.8%, P < 0.01) induction of anaesthesia, with fewer induction-related complications (11.8% vs 84.8%, P < 0.01) than did isoflurane. There was also greater patient acceptability of induction with sevoflurane (76.4% vs 42.4%, P < 0.05). Conclusion: In adults given midazolam premedication, isoflurane is not as suitable as sevoflurane for single VCB inhalational anaesthetic induction technique as it is associated with slower, more complicated induction and less patient acceptability.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANAESTHESIA
dc.description.sourcetitleCanadian Journal of Anaesthesia
dc.description.volume45
dc.description.issue10
dc.description.page949-953
dc.description.codenCJOAE
dc.identifier.isiutNOT_IN_WOS
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