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Title: Single vital capacity inhalational anesthetic induction in adults - Isoflurane vs sevoflurane
Authors: Lian Kah Ti 
Hwee Leng Pua
Tat Leang Lee 
Issue Date: 1998
Citation: Lian Kah Ti, Hwee Leng Pua, Tat Leang Lee (1998). Single vital capacity inhalational anesthetic induction in adults - Isoflurane vs sevoflurane. Canadian Journal of Anaesthesia 45 (10) : 949-953. ScholarBank@NUS Repository.
Abstract: Purpose: To evaluate whether isoflurane is as suitable as sevoflurane for the single vital capacity breath (VCB) method of inhalational induction in patients premedicated with midazolam. Methods: A randomised, controlled, double-blind study involving 67 ASA I-II patients aged between 18-50 yr undergoing elective surgery under general anaesthesia. All participants received premedication with 0.03 mg·kg-1 midazolam iv. Using a primed circle absorber circuit, inhalational induction of anaesthesia was performed with the single VCB method using either isoflurane 3.5% or sevoflurane 7.5% in nitrous oxide 67% in oxygen, representing approximately equivalent MAC- multiples of 3.6 MAC. Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction. Results: With the single VCB method, sevoflurane produced a faster (45 ± 21 vs 71 ± 22 sec, P < 0.01), more successful (100% vs 75.8%, P < 0.01) induction of anaesthesia, with fewer induction-related complications (11.8% vs 84.8%, P < 0.01) than did isoflurane. There was also greater patient acceptability of induction with sevoflurane (76.4% vs 42.4%, P < 0.05). Conclusion: In adults given midazolam premedication, isoflurane is not as suitable as sevoflurane for single VCB inhalational anaesthetic induction technique as it is associated with slower, more complicated induction and less patient acceptability.
Source Title: Canadian Journal of Anaesthesia
ISSN: 0832610X
Appears in Collections:Staff Publications

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