Please use this identifier to cite or link to this item: https://doi.org/10.1006/smim.2001.0341
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dc.titlePhospholipase D and immune receptor signalling
dc.contributor.authorMelendez, A.J.
dc.contributor.authorAllen, J.M.
dc.date.accessioned2016-11-29T01:22:37Z
dc.date.available2016-11-29T01:22:37Z
dc.date.issued2002
dc.identifier.citationMelendez, A.J., Allen, J.M. (2002). Phospholipase D and immune receptor signalling. Seminars in Immunology 14 (1) : 49-55. ScholarBank@NUS Repository. https://doi.org/10.1006/smim.2001.0341
dc.identifier.issn10445323
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131778
dc.description.abstractImmune receptors are coupled to the activation of phosphatidylcholine phospholipase D (PC-PLD) that hydrolyses phosphatidylcholine to generate phosphatidic acid and choline. As these receptors are also coupled to other signalling cascades, it has been difficult to define the precise cell activation events resulting from PLD activation in the absence of specific inhibitors. There is increasing evidence that phosphatidic acid acts as an intracellular signalling molecule regulating release of calcium from intracellular stores, sphingosine kinase and protein kinase C activation and membrane budding. Phosphatidic acid can also be rapidly converted into lysophosphatidic acid, diacylglycerol and arachidonates.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1006/smim.2001.0341
dc.sourceScopus
dc.subjectMacrophage activation
dc.subjectPhosphatidic acid
dc.subjectPhospholipase D
dc.typeReview
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1006/smim.2001.0341
dc.description.sourcetitleSeminars in Immunology
dc.description.volume14
dc.description.issue1
dc.description.page49-55
dc.description.codenSEIME
dc.identifier.isiut000174542800006
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