Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/131583
DC Field | Value | |
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dc.title | OX40 ligation of CD4+ T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4+ T regulatory cell inhibition | |
dc.contributor.author | Yu, Q. | |
dc.contributor.author | Yue, F.Y. | |
dc.contributor.author | Gu, X.X. | |
dc.contributor.author | Schwartz, H. | |
dc.contributor.author | Kovacs, C.M. | |
dc.contributor.author | Ostrowski, M.A. | |
dc.date.accessioned | 2016-11-29T01:20:21Z | |
dc.date.available | 2016-11-29T01:20:21Z | |
dc.date.issued | 2006-02-15 | |
dc.identifier.citation | Yu, Q., Yue, F.Y., Gu, X.X., Schwartz, H., Kovacs, C.M., Ostrowski, M.A. (2006-02-15). OX40 ligation of CD4+ T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4+ T regulatory cell inhibition. Journal of Immunology 176 (4) : 2486-2495. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00221767 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/131583 | |
dc.description.abstract | We have previously shown that CD4+ T cells are required to optimally expand viral-specific memory CD8+ CTL responses using a human dendritic cell-T cell-based coculture system. OX40 (CD134), a 50-kDa transmembrane protein of the TNFR family, is expressed primarily on activated CD4+ T cells. In murine models, the OX40/OX40L pathway has been shown to play a critical costimulatory role in dendritic cell/T cell interactions that may be important in promoting long-lived CD4+ T cells, which subsequently can help CD8+ T cell responses. The current study examined whether OX40 ligation on ex vivo CD4+ T cells can enhance their ability to "help" virus-specific CTL responses in HIV-1-infected and -uninfected individuals. OX40 ligation of CD4+ T cells by human OX40L-IgG1 enhanced the ex vivo expansion of HIV-1-specific and EBV-specific CTL from HIV-1-infected and -uninfected individuals, respectively. The mechanism whereby OX40 ligation enhanced help of CTL was independent of the induction of cytokines such as IL-2 or any inhibitory effect on CD4+ T regulatory cells, but was associated with a direct effect on proliferation of CD4 + T cells. Thus, OX40 ligation on CD4+ T cells represents a potentially novel immunotherapeutic strategy that should be investigated to treat and prevent persistent virus infections, such as HIV-1 infection. Copyright © 2006 by The American Association of Immunologists, Inc. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.sourcetitle | Journal of Immunology | |
dc.description.volume | 176 | |
dc.description.issue | 4 | |
dc.description.page | 2486-2495 | |
dc.description.coden | JOIMA | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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