Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.otohns.2007.06.714
DC FieldValue
dc.titlePotential non-immunoglobulin E-mediated food allergies: Comparison of open challenge and double-blind placebo-controlled food challenge
dc.contributor.authorWang, D.Y.
dc.contributor.authorGordon, B.R.
dc.contributor.authorChan, Y.H.
dc.contributor.authorYeoh, K.H.
dc.date.accessioned2016-11-29T01:20:12Z
dc.date.available2016-11-29T01:20:12Z
dc.date.issued2007-11
dc.identifier.citationWang, D.Y., Gordon, B.R., Chan, Y.H., Yeoh, K.H. (2007-11). Potential non-immunoglobulin E-mediated food allergies: Comparison of open challenge and double-blind placebo-controlled food challenge. Otolaryngology - Head and Neck Surgery 137 (5) : 803-809.e3. ScholarBank@NUS Repository. https://doi.org/10.1016/j.otohns.2007.06.714
dc.identifier.issn01945998
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/131570
dc.description.abstractObjective: Comparison of open food challenge (OFC) with double-blind placebo-controlled food challenge (DBPCFC). Study Design: Prospective sequential randomized challenges. Methods: Twenty adults with chronic allergy symptoms and at least 1 positive intradermal food wheal response recorded symptoms during DBPCFC and OFC provoked using organic foods, normal portions, and normal food preparation. Acoustic Rhinometry and biochemical tests were done during DBPCFC. Results: All patients reacted to at least 1 food and to all challenges with the same food, with multiorgan symptoms in the nose, nervous system, throat, and lung. There was a correlation in the type and severity of symptoms (P = 0.015) for OFC and DBPCFC, and both were significantly (P < 0.01) more severe than placebo. Compared with DBPCFC, OFC sensitivity was 66%, and positive predictive value was 89%. Conclusion: This is the first study showing both concordance of OFC and DBPCFC and also that intradermal tests can identify reactive foods that can be verified by DBPCFC. Because most tests for IgE-mediated food allergy were negative, observed reactions were probably non-IgE mediated. © 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.otohns.2007.06.714
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOTOLARYNGOLOGY
dc.description.doi10.1016/j.otohns.2007.06.714
dc.description.sourcetitleOtolaryngology - Head and Neck Surgery
dc.description.volume137
dc.description.issue5
dc.description.page803-809.e3
dc.description.codenOTOLD
dc.identifier.isiut000250821700021
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